Background: New drugs for the treatment of protozoal parasite infections such as toxoplasmosis and Hardy-Leindler-Type Inequalities via Conformable Delta Fractional Calculus leishmaniasis are required.Cinnamaldehyde and its derivatives appear to be promising antiparasitic drug candidates.Methods: Acyl hydrazones of cinnamaldehyde, 4-dimethylaminocinnamaldehyde, and of the synthetic fragrances silvialTM and florhydralTM were prepared and tested for activity against Toxoplasma gondii (T.gondii) and Leishmania major (L.
major) parasites.Results: Three cinnamaldehyde acyl hydrazones (3-hydroxy-2-naphthoyl 2a and the salicyloyls 2c and 2d) showed good activity against T.gondii, and two compounds FlexPES: a versatile soft X-ray beamline at MAX IV Laboratory derived from cinnamaldehyde and florhydralTM (3-hydroxy-2-naphthoyls 2a and 4a) exhibited moderate activity against L.major promastigotes.
Conclusions: In particular, the identified antitoxoplasmal activities are promising and might lead to the development of new potent and cost-effective drug candidates for the therapy of toxoplasmosis.